Abstract
(±)-Aspongamide A (1), an unusual trimer of N-acetyldopamine (NADA) bearing a novel tetrahydrobenzo[a]dibenzo[b,e][1,4]dioxine structure, and a pair of NADA dimeric enantiomers (2) were isolated from Aspongopus chinensis. The structures of compounds 1 and 2 were assigned using spectroscopic methods. Compound 1 was found to be an inhibitor of Smad3 phosphorylation in transforming growth factor-β1 (TGF-β1) induced rat renal proximal tubular cells and suppressed extracellular matrix expression in mesangial cells under diabetic conditions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Dopamine / analogs & derivatives*
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Dopamine / chemistry
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Dopamine / isolation & purification
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Dopamine / pharmacology
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Hemiptera / chemistry*
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Mesangial Cells / metabolism
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Phosphorylation
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RNA, Messenger / metabolism
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Rats
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Signal Transduction
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Smad3 Protein / antagonists & inhibitors*
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Transforming Growth Factor beta1 / metabolism
Substances
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RNA, Messenger
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Smad3 Protein
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Transforming Growth Factor beta1
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aspongamide A
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N-acetyldopamine
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Dopamine