An approach to pleomorphic sarcomas: can we subclassify, and does it matter?

Mod Pathol. 2014 Jan:27 Suppl 1:S39-46. doi: 10.1038/modpathol.2013.174.

Abstract

The term malignant fibrous histiocytoma (MFH) has been supplanted by undifferentiated pleomorphic sarcoma (UPS). Even now, however, a number of pleomorphic neoplasms are classified as UPSs when in fact at least a subgroup of these can be more precisely classified as a pleomorphic sarcoma with a specific line of differentiation. Still others are pseudosarcomas, most commonly sarcomatoid carcinomas. This review will discuss historical aspects of MFH/UPS as well as provide an approach to the pleomorphic malignant neoplasm with a discussion of useful ancillary techniques in the evaluation of such cases.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / analysis
  • Biomarkers, Tumor / genetics
  • Cell Dedifferentiation
  • Cell Differentiation
  • Diagnosis, Differential
  • Genetic Predisposition to Disease
  • Humans
  • Phenotype
  • Predictive Value of Tests
  • Prognosis
  • Sarcoma / chemistry
  • Sarcoma / classification*
  • Sarcoma / genetics
  • Sarcoma / pathology
  • Terminology as Topic*

Substances

  • Biomarkers, Tumor