Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

Nature. 1987 May 28-Jun 3;327(6120):298-303. doi: 10.1038/327298a0.

Abstract

RNAse A mismatch cleavage analysis of 66 primary human colon tumors reveals a high incidence of K-ras genes with mutations at position 12. No apparent correlation was found between the presence of mutant oncogenes and the degree of invasiveness of the tumours but evidence for ras mutational activation in premalignant tissue was obtained.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenocarcinoma / genetics
  • Adenocarcinoma / pathology
  • Adenoma / genetics
  • Adenoma / pathology
  • Aged
  • Aged, 80 and over
  • Codon
  • Colonic Neoplasms / genetics*
  • Colonic Neoplasms / pathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mutation*
  • Nucleic Acid Hybridization
  • Oncogenes*
  • RNA / genetics
  • RNA, Complementary
  • Ribonuclease, Pancreatic / metabolism

Substances

  • Codon
  • RNA, Complementary
  • RNA
  • Ribonuclease, Pancreatic