Calcitonin gene-related peptide and substance P in afferents to the upper gastrointestinal tract in the rat

Neurosci Lett. 1987 May 6;76(2):151-6. doi: 10.1016/0304-3940(87)90707-5.


Combined immunohistochemistry and retrograde tracing was used to investigate the origin of the sensory calcitonin gene-related peptide (CGRP) innervation of the rat stomach. Up to 85% of spinal gastric afferents (T6-L1) contained CGRP immunoreactivity compared with less than 6% of vagal gastric afferents. By comparison substance P immunoreactivity occurred in about 50% of spinal gastric afferents and less than 2% of vagal afferents. The vagal afferents to the oesophagus were 14 and 26% substance P- and CGRP-immunoreactive respectively. The results suggest an important role for CGRP in gastric spinal afferents.

MeSH terms

  • Animals
  • Calcitonin Gene-Related Peptide
  • Esophagus / innervation*
  • Fluorescent Antibody Technique
  • Ganglia, Spinal / metabolism
  • Male
  • Neurons, Afferent / metabolism
  • Neuropeptides / metabolism*
  • Nodose Ganglion / metabolism
  • Rats
  • Rats, Inbred Strains
  • Spinal Nerves / metabolism*
  • Stomach / innervation*
  • Substance P / metabolism*
  • Vagus Nerve / metabolism*


  • Neuropeptides
  • Substance P
  • Calcitonin Gene-Related Peptide