Mechanical thrombectomy for ischaemic stroke: the first UK case series

PLoS One. 2013 Dec 26;8(12):e82218. doi: 10.1371/journal.pone.0082218. eCollection 2013.

Abstract

Background and purpose: Endovascular treatments have the potential to accelerate reperfusion in acute ischaemic stroke with large vessel occlusion. In the UK only a few stroke centres offer this interventional option. The University Hospital of North Staffordshire (UHNS) has treated the largest number of cases in the UK. Results of the first 106 endovascular treatments (EVT) are presented here.

Methods: All patients treated with EVT (intra-arterial thrombolysis (IAT), mechanical thrombectomy (MT) or both, or an attempt at intervention) for acute stroke at UHNS, Stoke-on-Trent, UK, were entered into a prospective register. Baseline demographic and clinical data, the National Institutes for Health Stroke Scale (NIHSS), imaging results including Thrombolysis in Cerebral Infarction (TICI) score, and complications were recorded. Mortality, and modified Rankin score (mRS) were assessed at 90 days.

Results: From December 2009 to January 2013 106 patients (mean age 64 years, median baseline NIHSS 18) were treated with EVT (thrombectomy ± IAT 83%, IAT alone 13%, neither 4%). Seventy-eight per cent of occlusions were in the anterior circulation. Intravenous bridging thrombolysis was performed in 81%. Revascularization was successful (TICI 2b/3) in 84%. The median time from stroke onset to the end of the procedure was 6 h 03 min. A good outcome (mRS ≤ 2) at 90 days was achieved in 48% with a mortality of 15%. Fatal or nonfatal symptomatic intracranial haemorrhage (sICH) within 10 days occurred in 9%. The median length of stay was 14 days (31% discharged home ≤ 7 days).

Conclusions: EVT led to good clinical outcomes in almost 50% of patients with severe strokes.

MeSH terms

  • Aged
  • Endovascular Procedures / adverse effects*
  • Endovascular Procedures / mortality
  • Female
  • Humans
  • Intracranial Hemorrhages / etiology
  • Male
  • Mechanical Thrombolysis / adverse effects*
  • Mechanical Thrombolysis / mortality
  • Middle Aged
  • Postoperative Complications
  • Prospective Studies
  • Stroke / surgery*
  • Thrombectomy / adverse effects*
  • Thrombectomy / methods
  • Thrombectomy / mortality
  • Treatment Outcome
  • United Kingdom

Grant support

The authors have no support or funding to report.