Introduction of a mathematical model for optimizing the drug release in the patient's body

Daru. 2014 Jan 3;22(1):1. doi: 10.1186/2008-2231-22-1.


Background: Drug release in a patient's body is of particular interest to the pharmaceutical industry. One of the most essential types of drug release is the gradual release based on a behavior, which is called a profile or modified release. The investigation of the time-oriented quality characteristic is one of the newest topics in the area of product design. There are already several approaches addressing this issue. In this paper, a mathematical model is proposed to find the suitable values of the controllable factors in a drug to achieve the profile of the drug release in the patient's body.

Results: The proposed method has several advantages over the existing methods.

Conclusion: The authors feel that by adjusting the control factors during the production process the drug release profile become closer to the reference profile.