The CD200-CD200R1 inhibitory signaling pathway: immune regulation and host-pathogen interactions

Adv Immunol. 2014;121:191-211. doi: 10.1016/B978-0-12-800100-4.00005-2.


The CD200:CD200R1 inhibitory signaling pathway has been implicated in playing a prominent role in limiting inflammation in a wide range of inflammatory diseases. CD200R1 signaling inhibits the expression of proinflammatory molecules including tumor necrosis factor, interferons, and inducible nitric oxide synthase in response to selected stimuli. Unsurprisingly, due to the regulatory role that CD200R1 plays in multiple inflammatory pathways, an increasing number of parasitic, bacterial, and viral pathogens exploit this pathway to suppress host defenses. A complete understanding of the pathways regulated by CD200R1 signaling and the diverse mechanisms that pathogens have evolved to manipulate the CD200:CD200R1 pathway can help identify clinical situations where targeting this interaction can be of therapeutic benefit. In this review, we compare CD200R1 to other pathogen-targeted inhibitory receptors and highlight how this signaling pathway is utilized by a diverse number of pathogens and, therefore, may represent a novel targeting strategy for the treatment of infectious diseases.

Keywords: CD200; CD200R1; Inflammation; Inhibitory receptors; Pathogens; Viruses.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Antigens, CD / physiology*
  • Antigens, Surface / physiology*
  • Extracellular Fluid / immunology
  • Extracellular Fluid / microbiology
  • Extracellular Fluid / virology
  • Host-Pathogen Interactions / genetics
  • Host-Pathogen Interactions / immunology*
  • Humans
  • Immunoglobulins / physiology
  • Inflammation / genetics
  • Inflammation / microbiology
  • Inflammation / virology
  • Influenza, Human / genetics
  • Influenza, Human / immunology
  • Influenza, Human / virology
  • Lectins, C-Type / physiology
  • Mice
  • Orexin Receptors
  • Orthomyxoviridae Infections / genetics
  • Orthomyxoviridae Infections / immunology
  • Receptors, Cell Surface / deficiency
  • Receptors, Cell Surface / physiology*
  • Receptors, KIR / administration & dosage
  • Receptors, KIR / genetics
  • Signal Transduction / genetics
  • Signal Transduction / immunology*


  • Antigens, CD
  • Antigens, Surface
  • CD200R1 protein, human
  • Immunoglobulins
  • Lectins, C-Type
  • Orexin Receptors
  • Receptors, Cell Surface
  • Receptors, KIR
  • antigens, CD200