Vitamin D sufficiency associates with an increase in anti-inflammatory cytokines after intense exercise in humans

Cytokine. 2014 Feb;65(2):134-7. doi: 10.1016/j.cyto.2013.12.004. Epub 2013 Dec 31.


The purpose of this study was to identify the influence of vitamin D status (insufficient vs. sufficient) on circulating cytokines and skeletal muscle strength after muscular injury. To induce muscular injury, one randomly selected leg (SSC) performed exercise consisting of repetitive eccentric-concentric contractions. The other leg served as the control. An averaged serum 25(OH)D concentration from two blood samples collected before exercise and on separate occasions was used to establish vitamin D insufficiency (<30ng/mL, n=6) and sufficiency (>30ng/mL, n=7) in young, adult males. Serum cytokine concentrations, single-leg peak isometric force, and single-leg peak power output were measured before and during the days following the exercise protocol. The serum IL-10 and IL-13 responses to muscular injury were significantly (both p<0.05) increased in the vitamin D sufficient group. The immediate and persistent (days) peak isometric force (p<0.05) and peak power output (p<0.05) deficits in the SSC leg after the exercise protocol were not ameliorated with vitamin D sufficiency. We conclude that vitamin D sufficiency increases the anti-inflammatory cytokine response to muscular injury.

Keywords: Cytokines; Skeletal muscle strength; Vitamin D.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Inflammatory Agents / blood*
  • Cytokines / blood*
  • Exercise / physiology*
  • Humans
  • Isometric Contraction
  • Leg / physiology
  • Male
  • Vitamin D / blood*


  • Anti-Inflammatory Agents
  • Cytokines
  • Vitamin D