Prolonged remission of juvenile-onset respiratory papillomatosis: a post-expositional role of the tetravalent anti-HPV vaccine?

Int J Pediatr Otorhinolaryngol. 2014 Feb;78(2):388-90. doi: 10.1016/j.ijporl.2013.12.013. Epub 2013 Dec 19.


Juvenile-onset recurrent respiratory papillomatosis (JORRP) is an HPV-related neoplasm affecting primarily the larynx. JORRP often requires repeated surgical debridement, which yield variable but generally moderate remission periods. We report the case of a 6-year-old boy with severe course JORRP since the age of 2, requiring tracheostomy, that underwent prolonged remission and was decannulated some months after administration of the HPV vaccine. The post-exposure use for the anti-HPV vaccine in JORRP is a topic of capital interest but still poorly characterized. Some published cases suggest a potential post-exposure role of the vaccine in JORRP, but prospective multicentric trials are still needed.

Keywords: Anti-HPV vaccine; Juvenile-onset recurrent respiratory papillomatosis.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Humans
  • Male
  • Papillomavirus Infections / diagnosis
  • Papillomavirus Infections / drug therapy*
  • Papillomavirus Infections / surgery
  • Papillomavirus Vaccines / administration & dosage*
  • Recurrence
  • Respiratory Tract Infections / diagnosis
  • Respiratory Tract Infections / drug therapy*
  • Respiratory Tract Infections / surgery


  • Papillomavirus Vaccines

Supplementary concepts

  • Recurrent respiratory papillomatosis