Look Ma, no PCNA: how DNA polymerase ε synthesizes long stretches of DNA without a processivity factor

Nat Struct Mol Biol. 2014 Jan;21(1):12-4. doi: 10.1038/nsmb.2749.


The long-awaited crystal structure of Saccharomyces cerevisiae DNA polymerase ε reveals a unique domain never before observed in family B DNA polymerases. This novel domain endows polymerase ε with a capacity for highly processive DNA synthesis.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • DNA / biosynthesis*
  • DNA Polymerase II / chemistry
  • DNA Polymerase II / metabolism*
  • Models, Molecular
  • Proliferating Cell Nuclear Antigen / metabolism*
  • Saccharomyces cerevisiae / enzymology


  • Proliferating Cell Nuclear Antigen
  • DNA
  • DNA Polymerase II