Guideline adherence for identification and hydration of high-risk hospital patients for contrast-induced nephropathy

BMC Nephrol. 2014 Jan 6:15:2. doi: 10.1186/1471-2369-15-2.


Background: Contrast-induced nephropathy (CIN) is a common cause of acute renal failure in hospital patients. To prevent CIN, identification and hydration of high-risk patients is important. Prevention of CIN by hydration of high-risk patients was one of the themes to be implemented in the Dutch Hospital Patient Safety Program. This study investigates to what extent high-risk patients are identified and hydrated before contrast administration. Hospital-related and admission-related factors associated with the hydration of high-risk patients are identified.

Methods: The adherence to the guideline concerning identification and hydration of high-risk patients for CIN was evaluated retrospectively in 4297 patient records between November 2011 and December 2012. A multilevel logistic regression analysis was used to investigate the association between hospital-related and patient-related factors and hydration.

Results: The mean percentage patients with a known estimated Glomerular Filtration Rate before contrast administration was 96.4%. The mean percentage high-risk patients for CIN was 14.6%. The mean percentage high-risk patients hydrated before contrast administration was 68.5% and was constant over time. Differences between individual hospitals explained 19% of the variation in hydration. The estimated Glomerular Filtration Rate value and admission department were statistically significantly associated with the execution of hydration.

Conclusion: The identification of high-risk patients was almost 100%, but the subsequent step in the prevention of CIN is less performed, as only two third of the high-risk patients were hydrated before contrast administration. Large variation between individual hospitals confirmed the difference in hospitals in correctly applying the guideline for preventing CIN.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Contrast Media / adverse effects*
  • Female
  • Fluid Therapy / methods*
  • Guideline Adherence / statistics & numerical data*
  • Hospitalization / statistics & numerical data
  • Humans
  • Kidney Diseases / chemically induced*
  • Kidney Diseases / epidemiology
  • Kidney Diseases / therapy*
  • Male
  • Middle Aged
  • Nephrology / standards*
  • Netherlands / epidemiology
  • Prevalence
  • Retrospective Studies
  • Risk Assessment


  • Contrast Media