[Spontaneous regression of breast cancer after biopsy. About two cases]

Gynecol Obstet Fertil. 2014 Apr;42(4):269-72. doi: 10.1016/j.gyobfe.2013.08.017. Epub 2014 Jan 3.
[Article in French]


We report two cases of spontaneous regression of breast cancer occurred in our institution. It was about a 34- and an 82-year-old patient. The examination revealed a palpable nodule. In both cases, biopsy revealed a negative immunohistochemical staining for estrogen and progesterone receptors, and HER-2 negative. Histological analysis of the surgical specimen found fibrous tissue rearrangement without carcinoma. In the first case, a sarcoidosis was diagnosed at the same time, the mediastinal nodes mimicked a metastatic cancer. These cases illustrate a rare phenomenon. The main hypothesis is a carcinoma- directed immune response triggered by the biopsy.

Keywords: Breast cancer; Cancer du sein; Régression spontanée; Sarcoidosis; Sarcoïdose; Spontaneous regression.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Aged, 80 and over
  • Biopsy*
  • Breast Neoplasms / immunology
  • Breast Neoplasms / pathology*
  • Carcinoma, Ductal, Breast / pathology
  • Female
  • Humans
  • Lymph Nodes / pathology
  • Mammography
  • Neoplasm Regression, Spontaneous*
  • Sarcoidosis / pathology