Antigen responsiveness during tuberculosis: regulatory interactions of T cell subpopulations and adherent cells

J Lab Clin Med. 1987 Jul;110(1):31-40.

Abstract

Previous studies from this laboratory demonstrated that adherent mononuclear cells selectively decreased in vitro tuberculin responses in some anergic patients with tuberculosis; subsequently this adherent suppressor cell was characterized as a monocyte. The current study of 41 patients with active pulmonary tuberculosis examined whether T cell subpopulations also acquired antigen-specific suppressor function during Mycobacterium tuberculosis infection, contributed to monocyte-mediated suppression of tuberculin responses, or both. Alteration in the numbers of circulating T-helper (Leu 3a) and T-suppressor (Leu 2a) cells was not observed in patients with tuberculosis, nor did Leu 2a cells selectively modulate in vitro tuberculin responses. The numbers of circulating T gamma cells, a subset of T cells identified by surface receptors for the Fc portion of IgG (Fc gamma R), was increased twofold in patients with active pulmonary tuberculosis. Depletion of T gamma cells from in vitro cell culture consistently and selectively increased tuberculin responsiveness of T cells from patients with tuberculosis. In addition, in the absence of T gamma cells, monocyte-mediated suppression of tuberculin responses was demonstrated in each patient observed. These studies demonstrate that during M. tuberculosis infection T gamma cells acquire antigen-specific suppressor cell activity and suggest that T gamma cells also contribution to immunoregulation modulating the expression of tuberculin-specific suppression by monocytes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Cell Adhesion
  • Epitopes / immunology*
  • Female
  • Humans
  • Lymphocyte Depletion
  • Male
  • Middle Aged
  • Phenotype
  • T-Lymphocytes, Regulatory
  • Tuberculosis, Pulmonary / immunology*

Substances

  • Epitopes