Inhibition of melanin content by Punicalagins in the super fruit pomegranate (Punica granatum)

J Cosmet Sci. Nov-Dec 2013;64(6):445-53.

Abstract

Current efforts to develop effective skin lightening products through the inhibition of melanin production have focused on compounds that inhibit the function and activity of tyrosinase, the rate-limiting enzyme in the melanin biosynthesis pathway. Synthetic tyrosinase inhibitors, such as hydroquinone, kojic acid, and arbutin, have been reported to cause skin irritation or acute dermatitis, raising concerns about the safety of these compounds. As a result, there is a need for safe natural ingredients that show effective skin lightening. In this report, we have identified a natural ingredient, pomegranate fruit extract, that inhibits melanin production in melanocytes and shows potential for use as a cosmetic skin lightening agent. In addition, we have identified a polyphenolic compound, punicalagins, as the active melanin inhibitor in pomegranate fruit extract based on its capacity to directly inhibit melanin production.

MeSH terms

  • Animals
  • Cell Survival / drug effects
  • Cells, Cultured
  • Ellagic Acid / isolation & purification
  • Ellagic Acid / pharmacology
  • Humans
  • Hydrolyzable Tannins / chemistry
  • Hydrolyzable Tannins / isolation & purification
  • Hydrolyzable Tannins / pharmacology*
  • Lythraceae / chemistry*
  • Melanins / antagonists & inhibitors*
  • Melanins / biosynthesis
  • Melanocytes / cytology
  • Melanocytes / drug effects*
  • Melanocytes / enzymology
  • Mice
  • Monophenol Monooxygenase / antagonists & inhibitors
  • Monophenol Monooxygenase / metabolism
  • Plant Extracts / chemistry*
  • Skin / cytology
  • Skin / drug effects
  • Skin / enzymology
  • Skin Lightening Preparations / chemistry
  • Skin Lightening Preparations / isolation & purification
  • Skin Lightening Preparations / pharmacology*
  • Skin Pigmentation / drug effects*

Substances

  • Hydrolyzable Tannins
  • Melanins
  • Plant Extracts
  • Skin Lightening Preparations
  • Ellagic Acid
  • punicalagin
  • Monophenol Monooxygenase