Relative contribution of obesity and serum adiponectin to the development of hypertension

Diabetes Res Clin Pract. 2014 Jan;103(1):51-6. doi: 10.1016/j.diabres.2013.09.018. Epub 2013 Dec 11.


Aims: The aim of this study was to investigate the association between serum adiponectin level and new-onset hypertension, and the relative contribution of obesity and low serum adiponectin levels to the development of hypertension in normotensive men and women.

Methods: We analyzed 1553 adults (584 men and 969 women) without hypertension, aged 40-70 years, who had participated in a cohort study in both time periods from 2005 to 2008 for baseline and 2008 to 2011 for follow-up. We divided participants into sex-specific tertiles according to serum adiponectin levels. We defined the highest tertile of serum adiponectin as 'high adiponectin'. Participants were then stratified into four groups: the non-obese with high adiponectin; the non-obese with low adiponectin; the obese with high adiponectin; and the obese with low adiponectin.

Results: During an average of 2.6 years of follow-up, 79 men (13.5%) and 99 women (10.2%) developed hypertension. Low serum adiponectin level was an independent predictor of new-onset hypertension in men (Odds Ratio[OR]: 1.99; 95% CI: 1.03-3.86). The Obese men with low adiponectin had an increased risk of new-onset hypertension compared with the control group (OR: 2.80; 95% CI: 1.35-5.81). In postmenopausal women, the obese subjects with low adiponectin had an increased risk of new-onset hypertension compared with the control group (OR: 2.41; 95% CI 1.16-5.04).

Conclusion: Low serum adiponectin levels were associated with an increased risk of new-onset hypertension in men and postmenopausal women.

Keywords: Adiponectin; CI; Epidemiology; HDL; Hypertension; KoGES-ARIRANG; LDL; NO; Obesity; Prospective study; RIA; TG; confidence intervals; high density lipoprotein cholesterol; hs-CRP; low density lipoprotein cholesterol; nitric oxide; radioimmunoassay; sensitivity C-reactive protein; the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population; triglycerides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / blood*
  • Adult
  • Aged
  • Biomarkers / blood*
  • Blood Pressure
  • Female
  • Follow-Up Studies
  • Humans
  • Hypertension / blood
  • Hypertension / etiology*
  • Hypertension / pathology
  • Male
  • Middle Aged
  • Obesity / blood
  • Obesity / complications*
  • Prognosis
  • Prospective Studies


  • Adiponectin
  • Biomarkers