A series of new N-(11H-Indeno[1,2-b]quinoxalin-11-ylidene)benzohydrazide derivatives (3a-3p) were synthesized and evaluated for their α-glucosidase inhibitory activity. The synthesized compounds 3d, 3f, 3g, 3k, 3n, 3p and 4 showed significant α-glucosidase inhibitory activity as compared to acrabose, a standard drug used to treat type II diabetes. Structures of the synthesized compounds were determined by using FT-IR, (1)H NMR, (13)C NMR, mass spectrometry and elemental analysis techniques.
Keywords: 1,2-Di(11H-indeno[2,1-b]quioxalin-11-ylidene)hydrazine; 11H-Indeno[1,2-b]quinoxalin-11-one; N-(11H-Indeno[1,2-b]quinoxalin-11-ylidene)benzohydrazides; α-Glucosidase inhibitors.
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