Incidence and risk of developing contrast-induced acute kidney injury following intravascular contrast administration in elderly patients

Clin Interv Aging. 2014;9:85-93. doi: 10.2147/CIA.S55157. Epub 2013 Dec 31.


Background: The purpose of this meta-analysis was to evaluate the epidemiology of contrast-induced acute kidney injury (CI-AKI) in the elderly.

Methods: A literature review was undertaken to determine the incidence of CI-AKI in individuals receiving intravascular contrast medium in the hospital setting.

Results: Twenty-two studies with 186,455 patients were identified. The pooled incidence of CI-AKI was 13.6% in 67,831 patients older than 65 years of age (95% confidence interval [CI] 10.1-18.2, I(2) =0.496). The pooled odds ratio of CI-AKI in the elderly was 2.55 (95% CI 1.85-3.52, I(2) =0.34). The high incidence of CI-AKI in the elderly was consistent across different administration route subgroups (intracoronary contrast medium group, 15.5% [95% CI 10.3-22.6]; intravenous contrast medium group, 12.4% [95% CI 8.0-18.8]).

Conclusion: Elderly patients are at greater risk for developing CI-AKI.

Keywords: angiography; contrast-induced acute kidney injury; enhanced computed tomography; epidemiology; meta-analysis.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Kidney Injury / chemically induced*
  • Acute Kidney Injury / epidemiology
  • Administration, Intravenous
  • Aged
  • Contrast Media / administration & dosage
  • Contrast Media / adverse effects*
  • Humans
  • Incidence
  • Risk Factors


  • Contrast Media