Azacitidine: 10 years later

Cancer Treat Rep. Jul-Aug 1987;71(7-8):737-46.

Abstract

Azacitidine has been undergoing clinical trials for almost 20 years and is internationally considered to have a useful place in the treatment of acute nonlymphocytic leukemia. However, its role in the various combinations for induction, intensification, maintenance, or relapse regimens has not yet been clearly defined. This review outlines the last 10 years' clinical experience with the drug in acute nonlymphocytic leukemia, analyzes what critical information has yet to be obtained, and suggests what phase III trials may still be feasible to gather that information.

Publication types

  • Clinical Trial
  • Comparative Study
  • Review

MeSH terms

  • Acute Disease
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Azacitidine / metabolism
  • Azacitidine / therapeutic use*
  • Child
  • Clinical Trials as Topic
  • DNA, Neoplasm / metabolism
  • Drug Administration Schedule
  • Drug Evaluation
  • Humans
  • Kinetics
  • Leukemia / drug therapy*
  • Remission Induction

Substances

  • DNA, Neoplasm
  • Azacitidine