Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Jan 9;15:10.
doi: 10.1186/1471-2474-15-10.

Are Depression, Anxiety and Poor Mental Health Risk Factors for Knee Pain? A Systematic Review

Affiliations
Free PMC article
Review

Are Depression, Anxiety and Poor Mental Health Risk Factors for Knee Pain? A Systematic Review

Pyae P Phyomaung et al. BMC Musculoskelet Disord. .
Free PMC article

Abstract

Background: While it is recognized that psychosocial factors are important in the development and progression of musculoskeletal pain and disability, no systematic review has specifically focused on examining the relationship between psychosocial factors and knee pain. We aimed to systematically review the evidence to determine whether psychosocial factors, specifically depression, anxiety and poor mental health, are risk factors for knee pain.

Methods: Electronic searches of MEDLINE, EMBASE and PsycINFO were performed to identify relevant studies published up to August 2012 using MESH terms and keywords. We included studies that met a set of predefined criteria and two independent reviewers assessed the methodological quality of the selected studies. Due to the heterogeneity of the studies, a best evidence synthesis was performed.

Results: Sixteen studies were included in the review, of which 9 were considered high quality. The study populations were heterogeneous in terms of diagnosis of knee pain. We found a strong level of evidence for a relationship between depression and knee pain, limited evidence for no relationship between anxiety and knee pain, and minimal evidence for no relationship between poor mental health and knee pain.

Conclusions: Despite the heterogeneity of the included studies, these data show that depression plays a significant role in knee pain, and that a biopsychosocial approach to the management of this condition is integral to optimising outcomes for knee pain.

Figures

Figure 1
Figure 1
Flow diagram of included and excluded studies according to the PRISMA statement.

Similar articles

See all similar articles

Cited by 23 articles

See all "Cited by" articles

References

    1. Jinks C, Jordan K, Ong BN, Croft P. A brief screening tool for knee pain in primary care (KNEST). 2. Results from a survey in the general population aged 50 and over. Rheumatology. 2004;43(1):55–61. doi: 10.1093/rheumatology/keg438. - DOI - PubMed
    1. Bennell KL, Bowles KA, Payne C, Cicuttini F, Williamson E, Forbes A. et al. Lateral wedge insoles for medial knee osteoarthritis: 12 month randomised controlled trial. BMJ. 2011;342:d2912. doi: 10.1136/bmj.d2912. - DOI - PMC - PubMed
    1. Wang Y, Wluka A, Berry P, Siew T, Teichtahl A, Urquhart D. et al. Increase in vastus medialis cross-sectional area is associated with reduced pain, cartilage loss, and joint replacement risk in knee osteoarthritis. Arthritis Rheum. 2012;64(12):3917–3925. doi: 10.1002/art.34681. - DOI - PubMed
    1. Pincus T, Burton AK, Vogel S, Field AP. A systematic review of psychological factors as predictors of chronicity/disability in prospective cohorts of low back pain. Spine (Phila Pa 1976) 2002;27(5):E109–E120. doi: 10.1097/00007632-200203010-00017. - DOI - PubMed
    1. Christensen J, Knardahl S. Work and neck pain: a prospective study of psychological, social, and mechanical risk factors. Pain. 2010;151(1):162–173. doi: 10.1016/j.pain.2010.07.001. - DOI - PubMed
Feedback