Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's disease

Gastroenterology. 2014 Apr;146(4):929-31. doi: 10.1053/j.gastro.2013.12.034. Epub 2014 Jan 7.

Abstract

Increased dietary ratios of ω6/ω3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are limited. We investigated whether variants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along with the dietary ratio of ω6/ω3, confers susceptibility to CD. Based on data from 182 children newly diagnosed with CD and 250 controls, we found that children who consumed a higher dietary ratio of ω6/ω3 were susceptible for CD if they were also carriers of specific variants of CYP4F3 and FADS2 genes. Our findings implicate diet-gene interactions in the pathogenesis of CD.

Keywords: DNA; Fat Content; Food; Inflammatory Bowel Disease.

MeSH terms

  • Adolescent
  • Case-Control Studies
  • Child
  • Crohn Disease / enzymology
  • Crohn Disease / etiology*
  • Crohn Disease / genetics
  • Cytochrome P-450 Enzyme System / genetics*
  • Cytochrome P-450 Enzyme System / metabolism
  • Cytochrome P450 Family 4
  • Fatty Acid Desaturases / genetics*
  • Fatty Acid Desaturases / metabolism
  • Fatty Acids, Omega-3 / adverse effects*
  • Fatty Acids, Omega-3 / metabolism
  • Fatty Acids, Omega-6 / adverse effects*
  • Fatty Acids, Omega-6 / metabolism
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Phenotype
  • Polymorphism, Single Nucleotide*
  • Risk Factors

Substances

  • Fatty Acids, Omega-3
  • Fatty Acids, Omega-6
  • Cytochrome P-450 Enzyme System
  • Cytochrome P450 Family 4
  • CYP4F3 protein, human
  • Fatty Acid Desaturases
  • FADS2 protein, human
  • delta-5 fatty acid desaturase

Supplementary concepts

  • Pediatric Crohn's disease