Adipose-derived stromal vascular fraction cells and platelet-rich plasma: basic and clinical evaluation for cell-based therapies in patients with scars on the face

J Craniofac Surg. 2014 Jan;25(1):267-72. doi: 10.1097/


Background: Actually, autologous fat grafts have many clinical applications in breast surgery, facial rejuvenation, buttock augmentation, and Romberg syndrome as well as a treatment of liposuction sequelae.

Objective: The aim of this article was to describe the preparation and isolation procedures for stromal vascular fraction (SVF), the preparation of platelet-rich plasma (PRP), and the clinical application in the treatment of the scar on the face.

Methods: Ten patients with burns sequelae (n = 6) and post-traumatic scars (n = 4) were treated with SVF-enhanced autologous fat grafts obtained by the Celution System. Another 10 patients with burns sequelae (n = 5) and post-traumatic scars (n = 5) were treated with fat grafting based on the Coleman technique mixed with 0.5 mL of PRP.To assess the effects of their treatment, the authors compared their results with those of a control group consisting of 10 patients treated with centrifuged fat.

Results: In the patients treated with SVF-enhanced autologous fat grafts, we observed a 63% maintenance of contour restoring after 1 year compared with only 39% of the control group (n = 10) treated with centrifuged fat graft (P < 0.0001). In the patients treated with fat grafting and PRP, we observed a 69% maintenance of contour restoring after 1 year compared with that of the control group (n = 10).

Conclusions: Autologous fat grafting is a good method for the correction of scars on the face instead of the traditional scar surgical excision.

Publication types

  • Comparative Study

MeSH terms

  • Adipocytes / transplantation*
  • Adipose Tissue / cytology*
  • Adipose Tissue / transplantation
  • Adult
  • Aged
  • Autografts / transplantation
  • Burns / surgery
  • Cicatrix / surgery*
  • Face / surgery*
  • Facial Injuries / surgery
  • Female
  • Follow-Up Studies
  • Humans
  • Middle Aged
  • Multipotent Stem Cells / transplantation
  • Patient Satisfaction
  • Plastic Surgery Procedures / methods*
  • Platelet-Rich Plasma / physiology*
  • Regeneration / physiology
  • Stromal Cells / transplantation
  • Treatment Outcome
  • Young Adult