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Review
. 2014 Aug;29(5):415-25.
doi: 10.1177/1533317513518651. Epub 2014 Jan 8.

The Potential Role of Chemokines in Alzheimer's Disease Pathogenesis

Gholamreza Azizi  1 , Nikoo Khannazer  2 , Abbas Mirshafiey  3
Affiliations
Free article
Review

The Potential Role of Chemokines in Alzheimer's Disease Pathogenesis

Gholamreza Azizi et al. Am J Alzheimers Dis Other Demen. 2014 Aug.
Free article

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder and leading cause of dementia, which begins with impaired memory. The neuropathological hallmarks of AD include destructive alterations of neurons by neurofibrillary tangles, neuritic amyloid plaques, and neuroinflammatory process in the brain. Chemokines have a major role in inflammatory cell attraction and glial cell activation and/or modulation in the central nervous system. Moreover, the clinical and immunopathological evidence could show dual key role of chemokines in their pro- and anti-inflammatory properties in AD. However, their effects in neurodegeneration and/or neuroprotection remain an area of investigation. This review article provides an overview of characteristic, cellular source and activity of chemokines, and their roles in neuronal glial cell interaction in AD.

Keywords: Alzheimer’s disease; CCL2; CCL3; CCL5; CX3CL1; CXCL12; CXCL8; MIF; chemokine; inflammation; neurodegeneration.

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