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Review
. 2014;4(1):5-13.
doi: 10.5681/apb.2014.002. Epub 2013 Dec 23.

Immunomodulatory Nature and Site Specific Affinity of Mesenchymal Stem Cells: A Hope in Cell Therapy

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Free PMC article
Review

Immunomodulatory Nature and Site Specific Affinity of Mesenchymal Stem Cells: A Hope in Cell Therapy

Parisa Lotfinegad et al. Adv Pharm Bull. .
Free PMC article

Abstract

Immunosuppressive ability of mesenchymal stem cells (MSCs), their differentiation properties to various specialized tissue types, ease of in vitro and in vivo expansion and specific migration capacity, make them to be tested in different clinical trials for the treatment of various diseases. The immunomodulatory effects of MSCs are less identified which probably has high clinically significance. The clinical trials based on primary research will cause better understanding the ability of MSCs in immunomodulatory applications and site specific migration in the optimization of therapy. So, this review focus on MSCs functional role in modulating immune responses, their ability in homing to tumor, their potency as delivery vehicle and their medical importance.

Keywords: Cell migration; Cell therapy; Immunomodulation; Mesenchymal stem cells.

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