Beneficial Effects of Black Yeast Derived 1-3, 1-6 Beta Glucan-Nichi Glucan in a Dyslipidemic Individual of Indian Origin--A Case Report

J Diet Suppl. 2014 Mar;11(1):1-6. doi: 10.3109/19390211.2013.859211. Epub 2014 Jan 10.


Dyslipidemia is a major risk factor for the development of cardiovascular diseases and statins are the common drugs used to correct dyslipidemia. Herein, we report a case where the subject was a nondiabetic, dyslipidemia patient on medication with Rosuvastatin. After the intake of Rosuvastatin, his triglycerides decreased to a minimum of 220 mg/dL. In order to augment the action of Rosuvastatin, he was advised to take 1.5 mg of Nichi Glucan food supplement, which is a 1,3-1,6 Beta Glucan derived from the black yeast, Aureobasidium pullulans, daily for 2 months. At the end of 2 months, his triglyceride levels decreased from 523 mg/dL (at start of the study) to 175 mg/dL. His VLDL levels, which were 104.6 mg/dL at the start of the study decreased to 35 mg/dL and the HDL cholesterol levels increased from 27 to 38 mg/dL. This is a first of its kind report on the effect of the black yeast derived 1,3-1,6 Beta Glucans on dyslipidemia not associated with diabetes. Thus supplementation of Nichi Glucan, 1,3- 1,6 Beta Glucan derived from the black yeast along with the routine medications was beneficial to treat dyslipidemia and a larger trial is needed to confirm the effects.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Products / pharmacology
  • Biological Products / therapeutic use
  • Cholesterol / blood*
  • Dietary Supplements*
  • Drug Therapy, Combination
  • Dyslipidemias / blood
  • Dyslipidemias / drug therapy*
  • Fluorobenzenes / pharmacology
  • Fluorobenzenes / therapeutic use*
  • Humans
  • India
  • Male
  • Middle Aged
  • Pyrimidines / pharmacology
  • Pyrimidines / therapeutic use*
  • Rosuvastatin Calcium
  • Sulfonamides / pharmacology
  • Sulfonamides / therapeutic use*
  • Triglycerides / blood*
  • Yeasts / chemistry*
  • beta-Glucans / pharmacology
  • beta-Glucans / therapeutic use*


  • Biological Products
  • Fluorobenzenes
  • Pyrimidines
  • Sulfonamides
  • Triglycerides
  • beta-Glucans
  • Rosuvastatin Calcium
  • Cholesterol