Biocompatible polysaccharide-based cryogels

Mater Sci Eng C Mater Biol Appl. 2014 Feb 1;35:164-70. doi: 10.1016/j.msec.2013.10.034. Epub 2013 Nov 11.


This study focuses on the development of novel biocompatible macroporous cryogels by electron-beam assisted free-radical crosslinking reaction of polymerizable dextran and hyaluronan derivatives. As a main advantage this straightforward approach provides highly pure materials of high porosity without using additional crosslinkers or initiators. The cryogels were characterized with regard to their morphology and their basic properties including thermal and mechanical characteristics, and swellability. It was found that the applied irradiation dose and the chemical composition strongly influence the material properties of the resulting cryogels. Preliminary cytotoxicity tests illustrate the excellent in vitro-cytocompatibility of the fabricated cryogels making them especially attractive as matrices in tissue regeneration procedures.

Keywords: Biocompatibility; Cell cultivation; Cryogel; Electron-beam; Polysaccharides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3 Cells
  • Animals
  • Biocompatible Materials / chemical synthesis*
  • Biocompatible Materials / toxicity
  • Cell Survival / drug effects
  • Cryogels / chemical synthesis*
  • Cryogels / toxicity*
  • Dextrans / chemistry*
  • Dextrans / radiation effects
  • Dextrans / toxicity*
  • Elastic Modulus
  • Electrons
  • Hardness
  • Hyaluronic Acid / chemistry*
  • Hyaluronic Acid / radiation effects
  • Hyaluronic Acid / toxicity*
  • Materials Testing
  • Mice
  • Thermal Conductivity


  • Biocompatible Materials
  • Cryogels
  • Dextrans
  • Hyaluronic Acid