A new itch to scratch for TSLP

Matthew J Turner; Baohua Zhou

doi:10.1016/j.it.2013.12.001

A new itch to scratch for TSLP

Trends Immunol. 2014 Feb;35(2):49-50. doi: 10.1016/j.it.2013.12.001. Epub 2014 Jan 9.

Authors

Matthew J Turner¹, Baohua Zhou²

Affiliations

¹ Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202, USA.
² Department of Pediatrics and Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address: zhoub@iu.edu.

Abstract

Atopic dermatitis (AD) is characterized by allergic inflammation and itch. Thymic stromal lymphopoietin (TSLP) is a pro-allergic cytokine implicated in AD. A paper in Cell transforms the understanding of the functional repertoire of TSLP in general and in AD in particular showing that TSLP can directly stimulate sensory neurons and provoke itch.

Publication types

Comment

MeSH terms

Animals
Cytokines / metabolism*
Dermatitis, Atopic / pathology*
Humans
Signal Transduction*

Substances

Cytokines

Grants and funding

R01 AI085046/AI/NIAID NIH HHS/United States