A small catalytic oligoribonucleotide

Nature. 1987 Aug;328(6131):596-600. doi: 10.1038/328596a0.

Abstract

A 19-nucleotide RNA fragment can cause rapid, highly specific cleavage of a 24-nucleotide RNA fragment under physiological conditions. Because each 19-mer can participate in many cleavage reactions, this molecule has all the properties associated with an RNA enzyme.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cations, Divalent
  • DNA
  • DNA-Directed RNA Polymerases / metabolism
  • Hydrogen-Ion Concentration
  • Kinetics
  • Magnesium / pharmacology
  • Magnesium Chloride
  • Oligoribonucleotides / metabolism*
  • RNA / biosynthesis
  • RNA, Catalytic
  • RNA, Ribosomal / metabolism*
  • T-Phages / enzymology
  • Templates, Genetic

Substances

  • Cations, Divalent
  • Oligoribonucleotides
  • RNA, Catalytic
  • RNA, Ribosomal
  • Magnesium Chloride
  • RNA
  • DNA
  • DNA-Directed RNA Polymerases
  • Magnesium