Signaling unmasked: Autophagy and catalase promote programmed cell death

Autophagy. 2014 Mar;10(3):520-1. doi: 10.4161/auto.27564. Epub 2014 Jan 7.


Autophagy contributes to the removal of harmful cellular refuse, whereas catalase plays an important protective role by detoxifying reactive oxygen species. We recently found that autophagy and catalase are also required for promoting programmed cell death induced during plant immune responses. Here we discuss the difficulties in identifying cell death effectors, which are also required to maintain cellular homeostasis, and how their prodeath roles were unmasked using an unbiased forward genetics approach.

Keywords: autophagy; catalase; cell death; plant defense; plant-microbe interactions.

Publication types

  • Review

MeSH terms

  • Apoptosis / physiology*
  • Autophagy / physiology*
  • Catalase / metabolism*
  • Plants / enzymology
  • Reactive Oxygen Species
  • Signal Transduction / physiology*


  • Reactive Oxygen Species
  • Catalase