PARS: a web server for the prediction of Protein Allosteric and Regulatory Sites

Bioinformatics. 2014 May 1;30(9):1314-5. doi: 10.1093/bioinformatics/btu002. Epub 2014 Jan 9.


The regulation of protein activity is a key aspect of life at the molecular level. Unveiling its details is thus crucial to understanding signalling and metabolic pathways. The most common and powerful mechanism of protein-function regulation is allostery, which has been increasingly calling the attention of medicinal chemists due to its potential for the discovery of novel therapeutics. In this context, PARS is a simple and fast method that queries protein dynamics and structural conservation to identify pockets on a protein structure that may exert a regulatory effect on the binding of a small-molecule ligand.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allosteric Regulation
  • Allosteric Site*
  • Internet
  • Ligands
  • Proteins / chemistry*
  • Proteins / metabolism
  • Software


  • Ligands
  • Proteins