On the power of experimental designs for the detection of linkage between marker loci and quantitative loci in crosses between inbred lines

Theor Appl Genet. 1976 Jan;47(1):35-9. doi: 10.1007/BF00277402.


The power of experiments aimed at detecting linkage between a quantitative locus and a marker locus, both segregating in the backross or F2 generation of a cross between two inbred lines, is examined. Given that the two lines are close to fixation for alternative alleles of both marker locus and quantitative locus, it is concluded that experiments involving a few thousand offspring should be able to detect close linkages involving quantitative loci (or groups of loci) having rather modest effects (i.e., that contribute, say, 1% of the total phenotypic variance in the F2).