Long-term immune responses to vaccination in HIV-infected patients: a systematic review and meta-analysis

Clin Infect Dis. 2014 Apr;58(8):1130-9. doi: 10.1093/cid/cit937. Epub 2014 Jan 10.


Vaccine-induced antibodies may wane more quickly in persons living with human immunodeficiency virus (HIV) than in healthy individuals. We reviewed the literature on vaccines routinely recommended in HIV-infected patients to estimate how seroprotection decreases over time in those who initially responded to immunization. For each study retrieved from the literature, the decrease of seroprotection was modeled with a log binomial generalized linear model, and data were pooled in a meta-analysis to provide estimates of seroprotection 2 and 5 years after the last vaccine administration. Our analyses confirmed that the duration of seroprotection was shorter in HIV-infected patients and that with current guidelines, a substantial proportion of patients would have lost protective antibodies before a booster was proposed. We therefore discuss the implications for the monitoring of antibody levels and timing of revaccination in these patients.

Keywords: HIV; meta-analysis; vaccination.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • HIV Infections / immunology*
  • Humans
  • Infant
  • Models, Statistical
  • Time Factors
  • Vaccination / methods*
  • Vaccines / administration & dosage*
  • Vaccines / immunology*
  • Young Adult


  • Vaccines