Kainic acid-induced terminal degeneration in the dorsal lateral geniculate of tree shrew

Brain Res. 1987 Jul 21;416(1):187-91. doi: 10.1016/0006-8993(87)91516-2.

Abstract

The dorsal lateral geniculate nucleus of tree shrews is very susceptible to the neurotoxic effects of kainic acid. In addition to neuronal loss, there is a profound loss of retinal terminals that is manifested through a disruption of anterograde transport of WGA/HRP from the retina to the kainic acid-lesioned area of the geniculate nucleus. The actions of kainic acid upon both the presynaptic terminals and geniculate neurons may be mediated by a glutamatergic pathway and questions the hypothesis that kainic acid is solely neuron-specific in its toxic action.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Geniculate Bodies / drug effects*
  • Geniculate Bodies / pathology
  • Horseradish Peroxidase
  • Kainic Acid / toxicity*
  • Nerve Degeneration / drug effects*
  • Nerve Endings / drug effects*
  • Retinal Ganglion Cells / metabolism
  • Tupaiidae / physiology*
  • Visual Pathways / drug effects
  • Visual Pathways / pathology
  • Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
  • Wheat Germ Agglutinins

Substances

  • Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
  • Wheat Germ Agglutinins
  • Horseradish Peroxidase
  • Kainic Acid