Potassium channel blockade induces rhythmic activity in a conditional burster neuron

Brain Res. 1987 Jul 28;416(2):381-6. doi: 10.1016/0006-8993(87)90923-1.

Abstract

In the lobster stomatogastric ganglion the Anterior Burster (AB) neuron loses its rhythmic bursting capabilities when isolated from all synaptic input. Here we report that compounds which reduce the current through several different types of potassium channels induce bursting in isolated AB neurons. These results suggest that when quiescent, this neuron has all the conductances necessary to support bursting, but bursting is actively inhibited by tonic potassium conductances.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 4-Aminopyridine
  • Action Potentials / drug effects
  • Aminopyridines / pharmacology
  • Animals
  • Apamin / pharmacology
  • Calcium / physiology*
  • Digestive System / innervation
  • Ion Channels / drug effects
  • Ion Channels / physiology*
  • Nephropidae / physiology*
  • Neurons / drug effects
  • Neurons / physiology*
  • Potassium / physiology
  • Tetraethylammonium Compounds / pharmacology

Substances

  • Aminopyridines
  • Ion Channels
  • Tetraethylammonium Compounds
  • Apamin
  • 4-Aminopyridine
  • Potassium
  • Calcium