The response to inositol: regulation of glycerolipid metabolism and stress response signaling in yeast

Chem Phys Lipids. 2014 May;180:23-43. doi: 10.1016/j.chemphyslip.2013.12.013. Epub 2014 Jan 10.

Abstract

This article focuses on discoveries of the mechanisms governing the regulation of glycerolipid metabolism and stress response signaling in response to the phospholipid precursor, inositol. The regulation of glycerolipid lipid metabolism in yeast in response to inositol is highly complex, but increasingly well understood, and the roles of individual lipids in stress response are also increasingly well characterized. Discoveries that have emerged over several decades of genetic, molecular and biochemical analyses of metabolic, regulatory and signaling responses of yeast cells, both mutant and wild type, to the availability of the phospholipid precursor, inositol are discussed.

Keywords: Glycerolipids; Inositol; Phosphatidic acid; Phosphatidylinositol; Sphingolipids; Stress response.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Glycerol / metabolism*
  • Humans
  • Inositol / biosynthesis
  • Inositol / metabolism*
  • Lipid Metabolism*
  • Mutation
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae / physiology
  • Stress, Physiological*

Substances

  • Inositol
  • Glycerol