A Case Cluster Demonstrating the Relationship Between HLA Concordance and Virologic and Disease Outcomes in Human Immunodeficiency Virus Infection

Virology. 2014 Jan 20;449:104-8. doi: 10.1016/j.virol.2013.11.012. Epub 2013 Nov 27.

Abstract

We present a detailed analysis of sexual HIV transmission from one source partner to two recipients. The HLA haplotypes between the source partner and one recipient were very similar with 7 out of 8 HLA alleles from four loci (HLA A, B, C and DRB) shared, while the other recipient shared only one allele. The immunologic outcomes between the two recipients differed dramatically, despite the absence of apparent virologic differences in their inoculums. We suggest that non-viral factors, which might be related to differences in the HLA profile, played a role in determining different CD4+ T-cells dynamics for these two recipients.

Keywords: Cellular immunity; Concordance; Disease progression; Evolution; HLA; Human immunodeficiency virus; Transmission.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Disease Progression
  • HIV Infections / genetics
  • HIV Infections / immunology*
  • HIV Infections / transmission
  • HIV Infections / virology*
  • HIV-1 / genetics
  • HIV-1 / physiology*
  • HLA Antigens / genetics
  • HLA Antigens / immunology*
  • Homosexuality, Male
  • Humans
  • Male
  • Young Adult

Substances

  • HLA Antigens