The membrane insertase YidC

Ross E Dalbey; Andreas Kuhn; Lu Zhu; Doro Kiefer

doi:10.1016/j.bbamcr.2013.12.022

The membrane insertase YidC

Biochim Biophys Acta. 2014 Aug;1843(8):1489-96. doi: 10.1016/j.bbamcr.2013.12.022. Epub 2014 Jan 10.

Authors

Ross E Dalbey¹, Andreas Kuhn², Lu Zhu³, Doro Kiefer⁴

Affiliations

¹ Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA. Electronic address: dalbey@chemistry.ohio-state.edu.
² Institute of Microbiology and Molecular Biology, University of Hohenheim, Garbenstr 30, 70599 Stuttgart, Germany. Electronic address: Andreas.Kuhn@uni-hohenheim.de.
³ Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
⁴ Institute of Microbiology and Molecular Biology, University of Hohenheim, Garbenstr 30, 70599 Stuttgart, Germany.

PMID: 24418623
DOI: 10.1016/j.bbamcr.2013.12.022

Abstract

The membrane insertases YidC-Oxa1-Alb3 provide a simple cellular system that catalyzes the transmembrane topology of newly synthesized membrane proteins. The insertases are composed of a single protein with 5 to 6 transmembrane (TM) helices that contact hydrophobic segments of the substrate proteins. Since YidC also cooperates with the Sec translocase it is widely involved in the assembly of many different membrane proteins including proteins that obtain complex membrane topologies. Homologues found in mitochondria (Oxa1) and thylakoids (Alb3) point to a common evolutionary origin and also demonstrate the general importance of this cellular process. This article is part of a Special Issue entitled: Protein trafficking and secretion in bacteria. Guest Editors: Anastassios Economou and Ross Dalbey.

Keywords: Membrane insertase; Membrane targeting; Mitochondrion; Sec translocase; Thylakoid; Topology.

Publication types

Review

MeSH terms

Adenosine Triphosphatases / genetics
Adenosine Triphosphatases / metabolism
Bacterial Proteins / genetics
Bacterial Proteins / metabolism
Electron Transport Complex IV / chemistry
Electron Transport Complex IV / metabolism
Escherichia coli / genetics
Escherichia coli Proteins / chemistry
Escherichia coli Proteins / metabolism
Membrane Transport Proteins / chemistry
Membrane Transport Proteins / genetics
Membrane Transport Proteins / metabolism*
Mitochondrial Proteins / biosynthesis
Mitochondrial Proteins / chemistry
Mitochondrial Proteins / metabolism*
Nuclear Proteins / chemistry
Nuclear Proteins / metabolism
Protein Folding
Protein Transport / genetics*
SEC Translocation Channels
SecA Proteins
Thylakoid Membrane Proteins / biosynthesis
Thylakoid Membrane Proteins / metabolism*

Substances

Bacterial Proteins
Escherichia coli Proteins
Membrane Transport Proteins
Mitochondrial Proteins
Nuclear Proteins
OXA1 protein
SEC Translocation Channels
Thylakoid Membrane Proteins
YIDC protein, E coli
Electron Transport Complex IV
Adenosine Triphosphatases
SecA Proteins