Discovering the Hippo Pathway Protein-Protein Interactome

Cell Res. 2014 Feb;24(2):137-8. doi: 10.1038/cr.2014.6. Epub 2014 Jan 14.

Abstract

The Hippo pathway is a signal transduction pathway that regulates organ growth, stem cell biology, regeneration and cancer. Three recent proteomic studies with Hippo pathway components uncovered extensive networks of interacting proteins revealing novel connections to cell-cell junctions, regulation by vesicle trafficking, and phosphorylation-dependent remodeling of the interactome, and provide a rich landscape of novel interactors ripe for mechanistic studies.

MeSH terms

  • Animals
  • Cytoskeleton / metabolism
  • Drosophila
  • Humans
  • Nuclear Proteins / metabolism
  • Phosphorylation
  • Protein Interaction Maps*
  • Protein Transport
  • Protein-Serine-Threonine Kinases / metabolism*
  • RNA Interference
  • Signal Transduction
  • Tight Junction Proteins / metabolism
  • Transcription Factors / metabolism

Substances

  • Nuclear Proteins
  • Tight Junction Proteins
  • Transcription Factors
  • Hippo protein, human
  • Protein-Serine-Threonine Kinases