Mast cell activation--a receptor-independent mode of substance P action?

FEBS Lett. 1987 Sep 14;221(2):236-40. doi: 10.1016/0014-5793(87)80932-8.


Substance P is a representative of a group of amphiphilic neuropeptides which act as mast cell secretagogues. Our experiments with some new substance P derivatives suggest that these effects are dependent on two structural elements: (i) a hydrophobic chain which is not essentially a peptide, and (ii) a hydrophilic part with two positively charged amino acids. The mast cell triggering effect is unlikely to be mediated by a selective substance P receptor, but has strong similarities to the mode of action of polycations.

MeSH terms

  • Animals
  • Histamine Release / drug effects
  • Male
  • Mast Cells / drug effects*
  • Mast Cells / metabolism
  • Rats
  • Rats, Inbred Strains
  • Receptors, Neurokinin-1
  • Receptors, Neurotransmitter / drug effects*
  • Structure-Activity Relationship
  • Substance P / pharmacology*


  • Receptors, Neurokinin-1
  • Receptors, Neurotransmitter
  • Substance P