Grb10 is a dual regulator of receptor tyrosine kinase signaling

Mol Biol Rep. 2014;41(4):1985-92. doi: 10.1007/s11033-014-3046-4. Epub 2014 Jan 14.

Abstract

The adaptor protein Grb10 is a close homolog of Grb7 and Grb14. These proteins are characterized by an N-terminal proline-rich region, a Ras-GTPase binding domain, a PH domain, an SH2 domain and a BPS domain in between the PH and SH2 domains. Human Grb10 gene encodes three splice variants. These variants show differences in functionality. Grb10 associates with multiple proteins including tyrosine kinases in a tyrosine phosphorylation dependent or independent manner. Association with multiple proteins allows Grb10 to regulate different signaling pathways resulting in different biological consequences.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alternative Splicing
  • Animals
  • ErbB Receptors / metabolism
  • GRB10 Adaptor Protein / chemistry
  • GRB10 Adaptor Protein / genetics
  • GRB10 Adaptor Protein / metabolism*
  • Gene Expression
  • Humans
  • Protein Interaction Domains and Motifs
  • Receptor Protein-Tyrosine Kinases / metabolism*
  • Receptor, Insulin / metabolism
  • Receptors, Vascular Endothelial Growth Factor / metabolism
  • Signal Transduction*
  • src Homology Domains

Substances

  • GRB10 Adaptor Protein
  • ErbB Receptors
  • Receptor Protein-Tyrosine Kinases
  • Receptor, Insulin
  • Receptors, Vascular Endothelial Growth Factor