Molecular genetics of the VDAC ion channel: structural model and sequence analysis

J Bioenerg Biomembr. 1987 Aug;19(4):341-50. doi: 10.1007/BF00768537.


The voltage-dependent anion-selective channel of the outer mitochondrial membrane provides a unique system in which to study the molecular basis of voltage gating of ion flow. We have cloned and sequenced a cDNA coding for this protein in yeast. From the derived amino acid sequence, we have generated a preliminary model for the secondary structure of the protein which suggests that the protein forms a "beta-barrel" type structure. Comparison of the VDAC amino acid sequence with that of the bacterial porins has indicated that the two classes of molecules appear to be unrelated.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Genes*
  • Genes, Fungal*
  • Ion Channels / physiology
  • Membrane Proteins / genetics*
  • Mitochondria / physiology*
  • Porins*
  • Saccharomyces cerevisiae / genetics
  • Voltage-Dependent Anion Channels


  • Ion Channels
  • Membrane Proteins
  • Porins
  • Voltage-Dependent Anion Channels