Risk of stroke associated with nonsteroidal anti-inflammatory drugs

Vasc Health Risk Manag. 2014;10:25-32. doi: 10.2147/VHRM.S54159. Epub 2014 Jan 6.


Nonsteroidal anti-inflammatory drugs (NSAIDs), both cyclooxygenase (COX)-2-selective and nonselective agents, have been associated with the increased risk of adverse cardiovascular events. The majority of studies have focused on myocardial infarction as the primary cardiovascular outcome. However, the association between NSAIDs and the risk of stroke events is not as clear, although an understanding of this association is important since stroke continues to be a significant cause of morbidity and mortality. Various factors may contribute to an association between NSAIDs and stroke, including hypertension and thrombosis. Additionally, the risk may vary with different NSAID types. In this review, we discuss the relevant literature assessing the possible association between NSAID use and stroke events, along with the potential mechanisms and the possible directions for future study.

Keywords: adverse events; cardiovascular; cyclooxygenase; nonsteroidal anti-inflammatory drugs; stroke.

Publication types

  • Review
  • Video-Audio Media

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Comorbidity
  • Humans
  • Prevalence
  • Risk Assessment
  • Risk Factors
  • Stroke / chemically induced*
  • Stroke / mortality


  • Anti-Inflammatory Agents, Non-Steroidal