Potential consequences of essential drug shortages in Canada: Brain abscess due to Nocardia farcinica associated with dapsone prophylaxis for Pneumocystis jirovecii pneumonia
- PMID: 24421828
- PMCID: PMC3852454
- DOI: 10.1155/2013/805797
Potential consequences of essential drug shortages in Canada: Brain abscess due to Nocardia farcinica associated with dapsone prophylaxis for Pneumocystis jirovecii pneumonia
Abstract
In 2012, Canadian pharmacies experienced a shortage of trimethoprim-sulfamethoxazole tablets. Drug shortages may result in unintended clinical consequences such as infection with pathogens against which the alternative medication is ineffective. This is highlighted in the present article, which describes a case of brain abscess due to Nocardia species that developed while receiving dapsone as an alternative for prophylaxis against Pneumocystis jirovecii pneumonia in a highly immune-suppressed patient. Clinicians should be cognizant of these issues when prescribing alternative agents.
En 2012, les pharmacies canadiennes ont subi une pénurie de comprimés de triméthoprim-sulfaméthoxazole. Les pénuries de médicaments peuvent avoir des conséquences non intentionnelles, telles qu’une infection par des pathogènes contre lesquels le médicament de remplacement n’a pas d’effets. C’est ce qu’on souligne dans le présent article, qui décrit un cas d’abcès cérébral attribuable à une espèce de Nocardia qui s’est manifesté pendant l’administration de dapsone en prophylaxie de remplacement contre une pneumonie à Pneumocystis jirovecii chez un patient très immunodéprimé. Les cliniciens devraient connaître ces enjeux lorsqu’ils prescrivent des médicaments de remplacement.
Keywords: Drug shortage; Nocardia; PCP prophylaxis; Pneumocystis jirovecii; Trimethoprim-sulfamethoxazole.
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