Family-based association study between monoamine oxidase A (MAOA) gene promoter VNTR polymorphism and Tourette's syndrome in Chinese Han population

Shiguo Liu; Xueqin Wang; Longqiang Xu; Lanlan Zheng; Yinlin Ge; Xu Ma

doi:10.1080/13554794.2013.873061

Family-based association study between monoamine oxidase A (MAOA) gene promoter VNTR polymorphism and Tourette's syndrome in Chinese Han population

Neurocase. 2015 Feb;21(1):106-8. doi: 10.1080/13554794.2013.873061. Epub 2014 Jan 14.

Authors

Shiguo Liu¹, Xueqin Wang, Longqiang Xu, Lanlan Zheng, Yinlin Ge, Xu Ma

Affiliation

¹ a Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Medical College , Qingdao University , Qingdao 266003 , China.

PMID: 24422758
DOI: 10.1080/13554794.2013.873061

Abstract

To clarify the association of monoamine oxidase A- variable number of tandem repeat (MAOA-pVNTR) with susceptibility to Tourette's syndrome (TS) in Chinese Han population we discuss the genetic contribution of MAOA-VNTR in 141 TS patients including all their parents in Chinese Han population using transmission disequilibrium test (TDT) design. Our results revealed that no significant association was found in the MAOA gene promoter VNTR polymorphism and TS in Chinese Han population (TDT = 1.515, df = 1, p > 0.05). The negative result may be mainly due to the small sample size, but we don't deny the role of gene coding serotonergic or monoaminergic structures in the etiology of TS.

Keywords: MAOA; TDT; TS; VNTR.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Asian People
Child
Child, Preschool
Family
Female
Genetic Association Studies
Humans
Male
Minisatellite Repeats*
Monoamine Oxidase / genetics*
Polymorphism, Genetic
Promoter Regions, Genetic
Tourette Syndrome / genetics*

Substances

Monoamine Oxidase
monoamine oxidase A, human