The Cache County Study on Memory in Aging: factors affecting risk of Alzheimer's disease and its progression after onset

Int Rev Psychiatry. 2013 Dec;25(6):673-85. doi: 10.3109/09540261.2013.849663.


The Cache County Study on Memory in Aging is a longitudinal, population-based study of Alzheimer's disease (AD) and other dementias. Initiated in 1995 and extending to 2013, the study has followed over 5,000 elderly residents of Cache County, Utah (USA) for over twelve years. Achieving a 90% participation rate at enrolment, and spawning two ancillary projects, the study has contributed to the literature on genetic, psychosocial and environmental risk factors for AD, late-life cognitive decline, and the clinical progression of dementia after its onset. This paper describes the major study contributions to the literature on AD and dementia.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / physiology
  • Alzheimer Disease / drug therapy
  • Alzheimer Disease / epidemiology*
  • Alzheimer Disease / genetics
  • Cognition Disorders / drug therapy
  • Cognition Disorders / epidemiology*
  • Cognition Disorders / genetics
  • Disease Progression
  • Female
  • Humans
  • Incidence
  • Male
  • Memory / physiology
  • Prevalence
  • Prospective Studies
  • Risk Factors
  • Stress, Psychological / complications
  • Stress, Psychological / epidemiology
  • Utah / epidemiology