Posterior capsule opacification and neodymium:YAG rates with 2 single-piece hydrophobic acrylic intraocular lenses: three-year results

J Cataract Refract Surg. 2013 Dec;39(12):1886-92. doi: 10.1016/j.jcrs.2013.06.021.


Purpose: To compare the incidence and intensity of posterior capsule opacification (PCO) between 2 similar 1-piece foldable hydrophobic acrylic intraocular lenses (IOLs) over 3 years.

Setting: Department of Ophthalmology, Medical University Vienna, Vienna, Austria.

Design: Randomized prospective patient- and examiner-masked clinical trial with intraindividual comparison.

Methods: Patients with bilateral age-related cataract had cataract surgery and implantation of a Tecnis ZCB00 continuous-optic-edge IOL in 1 eye and an Acrysof SA60AT interrupted-optic-edge IOL in the other eye. Postoperative examinations were performed at 6 months and 3 years. Digital retroillumination images were taken of each eye. The amount of PCO (score 0 to 10) was assessed subjectively at the slitlamp and objectively using automated image-analysis software.

Results: The study comprised 54 patients (108 eyes). The mean objective PCO score was 1.3 ± 1.7 (SD) for the continuous-optic-edge IOLs and 0.9 ± 1.3 for the interrupted-optic-edge IOLs (P=.10). Three years postoperatively, a neodymium:YAG (Nd:YAG) capsulotomy was performed in 26.1% of eyes with the continuous-optic-edge IOL and 21.7% with the interrupted-optic-edge IOL (P=.56). There was no significant difference in corrected distance visual acuity, capsulorhexis–IOL overlap, capsule folds, or anterior capsule opacification 3 years after surgery.

Conclusions: Both IOLs had comparable PCO and Nd:YAG rates 3 years postoperatively. The optimized barrier function of the continuous-optic-edge IOL and the material properties of the interrupted-optic-edge IOL seemingly outbalanced the effect on lens epithelial cell migration and proliferation beneath the optic.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Acrylic Resins
  • Aged
  • Capsule Opacification / epidemiology*
  • Capsule Opacification / etiology
  • Capsule Opacification / surgery
  • Double-Blind Method
  • Female
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Incidence
  • Lasers, Solid-State / therapeutic use*
  • Lens Implantation, Intraocular
  • Lenses, Intraocular*
  • Male
  • Phacoemulsification
  • Posterior Capsule of the Lens / pathology*
  • Posterior Capsule of the Lens / surgery
  • Posterior Capsulotomy / statistics & numerical data*
  • Postoperative Complications*
  • Prospective Studies
  • Visual Acuity / physiology


  • Acrylic Resins