Efficacy and side-effect profiles of lactulose, docusate sodium, and sennosides compared to PEG in opioid-induced constipation: a systematic review
Can Oncol Nurs J. 2013 Autumn;23(4):236-46.
doi: 10.5737/1181912x234236240.
[Article in
English,
French]
Affiliations
- 1 Royal Alexandra Hospital, Alberta Thoracic Oncology Program/Chest Medicine Clinic, Room 4505 Children's Centre, Royal Alexandra Hospital, 10240 Kingsway Ave., Edmonton, AB T5H 3V9. Teresa.Ruston@albertahealthservices.ca
- 2 Faculty of Medicine, Division of Geriatric Medicine, Faculty of Nursing Level 3, Edmonton Clinic Health Academy, 11405 87 Ave., University of Alberta, Edmonton, AB T6G C9.
- 3 Division of Gastroenterology, 2-30A Zeidler-Ledcor, 130 University Campus, University of Alberta, Edmonton, AB T6G 2X8.
Abstract
Opioid-induced constipation (OIC) is a side effect of opioid therapy that can affect quality of life, adherence to treatment, and morbidity and possibly mortality.
Objectives:
To investigate whether docusate sodium, sennosides, and lactulose have equal efficacy and side effect profiles compared to PEG in the management of OIC in adults.
Methods:
A systematic review was undertaken. Randomized controlled trials of adults taking opioids for cancer or non-cancer pain were considered if they met inclusion criteria.
Conclusions:
Statistical pooling was not possible as no studies met inclusion criteria. Large, well-powered, randomized controlled trials are feasible. Standard definitions of OIC would assist with the execution of these studies and contribute to their internal and external validity. Further research is strongly encouraged.
Publication types
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Research Support, Non-U.S. Gov't
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Review
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Systematic Review
MeSH terms
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Adult
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Analgesics, Opioid / adverse effects*
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Cathartics / adverse effects
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Cathartics / pharmacology
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Cathartics / therapeutic use
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Constipation / chemically induced
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Constipation / drug therapy*
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Dioctyl Sulfosuccinic Acid / adverse effects
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Dioctyl Sulfosuccinic Acid / pharmacology
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Dioctyl Sulfosuccinic Acid / therapeutic use
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Humans
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Lactulose / adverse effects
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Lactulose / pharmacology
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Lactulose / therapeutic use
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Laxatives / adverse effects
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Laxatives / pharmacology
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Laxatives / therapeutic use*
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Polyethylene Glycols / adverse effects
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Polyethylene Glycols / pharmacology
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Polyethylene Glycols / therapeutic use
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Senna Extract / adverse effects
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Senna Extract / pharmacology
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Senna Extract / therapeutic use
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Surface-Active Agents / adverse effects
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Surface-Active Agents / pharmacology
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Surface-Active Agents / therapeutic use
Substances
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Analgesics, Opioid
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Cathartics
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Laxatives
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Surface-Active Agents
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Dioctyl Sulfosuccinic Acid
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Polyethylene Glycols
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Lactulose
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Senna Extract