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Review
. Autumn 2013;23(4):236-46.
doi: 10.5737/1181912x234236240.

Efficacy and Side-Effect Profiles of Lactulose, Docusate Sodium, and Sennosides Compared to PEG in Opioid-Induced Constipation: A Systematic Review

[Article in English, French]
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Review

Efficacy and Side-Effect Profiles of Lactulose, Docusate Sodium, and Sennosides Compared to PEG in Opioid-Induced Constipation: A Systematic Review

[Article in English, French]
Teresa Ruston et al. Can Oncol Nurs J. .

Abstract

Opioid-induced constipation (OIC) is a side effect of opioid therapy that can affect quality of life, adherence to treatment, and morbidity and possibly mortality.

Objectives: To investigate whether docusate sodium, sennosides, and lactulose have equal efficacy and side effect profiles compared to PEG in the management of OIC in adults.

Methods: A systematic review was undertaken. Randomized controlled trials of adults taking opioids for cancer or non-cancer pain were considered if they met inclusion criteria.

Conclusions: Statistical pooling was not possible as no studies met inclusion criteria. Large, well-powered, randomized controlled trials are feasible. Standard definitions of OIC would assist with the execution of these studies and contribute to their internal and external validity. Further research is strongly encouraged.

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