No longer merely a concept for the future, the use of digital technologies in dentistry has become common practice today. Computed tomography (CT)-guided dental implant surgery has greatly expanded over the past decade as concepts and techniques have become increasingly refined and more implant manufacturers have adapted their implant systems to these new technologies. The All-on-4® technique for dental implant placement and restoration, while developed some two decades ago, has recently generated increased interest as a highly functional, esthetic, cost-effective alternative for a large group of patients who could benefit from a full-arch, implant-supported fixed restoration. The authors ask, "Are these two technologies a marriage made in heaven?" This article describes the All-on-4 CT-guided surgery technique and reports on the treatment findings on three patients, each with different prosthodontic management.