Lindane neurotoxic reaction in nonbullous congenital ichthyosiform erythroderma

Arch Dermatol. 1987 Aug;123(8):1056-8.


A 3-year-old boy with nonbullous congenital ichthyosiform erythroderma with a four-month history of scabies was treated with a single dose of lindane cream. In a 48-hour period, he developed nausea and vomiting and also suffered from an epileptiform convulsion and muscular spasms. Seventy-two hours after application of the cream, his blood lindane level was 54 ng/mL. Caution should be exercised when using lindane in patients with compromised epidermal barrier function.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Hexachlorocyclohexane / adverse effects*
  • Hexachlorocyclohexane / therapeutic use
  • Humans
  • Ichthyosis / congenital*
  • Male
  • Scabies / drug therapy*
  • Seizures / chemically induced*
  • Spasm / chemically induced


  • Hexachlorocyclohexane