Functional gastrointestinal disorders in patients with familial Mediterranean fever

Int J Rheum Dis. 2017 Dec;20(12):2101-2105. doi: 10.1111/1756-185X.12207. Epub 2013 Oct 29.


Aim: Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disease characterised by recurrent episodes of fever and polyserositis. To date, insufficient data regarding the prevalence of functional gastrointestinal disorders such as irritable bowel syndrome (IBS) and functional dyspepsia (FD) have been reported in patients with FMF. This study aimed to determine the prevalence of functional gastrointestinal disorders in patients with FMF.

Methods: This study included 122 patients with FMF and a control group of 122 healthy volunteers who were similar with respect to age and sex. Clinical data were collected and gastrointestinal complaints were evaluated according to the Rome III criteria.

Results: IBS was found in 18% of the patients and 10.7% of the controls (P > 0.05). Dyspepsia was reported in 37.7% of the patients and 35.2% of the controls. Constipation was significantly higher in the control group (15.6% vs. 7.4%, P = 0.045), whereas diarrhoea was reported significantly more often in patients with FMF (P = 0.001).

Conclusions: IBS and dyspepsia were not increased in patients with FMF, whereas diarrhoea was more frequently reported.

Keywords: Rome criteria; dyspepsia; familial Mediterranean fever; functional gastrointestinal disorders; irritable bowel syndrome.

MeSH terms

  • Adult
  • Constipation / epidemiology
  • Cross-Sectional Studies
  • Diarrhea / epidemiology
  • Dyspepsia / epidemiology
  • Familial Mediterranean Fever / diagnosis
  • Familial Mediterranean Fever / epidemiology*
  • Female
  • Gastrointestinal Diseases / diagnosis
  • Gastrointestinal Diseases / epidemiology*
  • Humans
  • Incidence
  • Irritable Bowel Syndrome / epidemiology
  • Male
  • Middle Aged
  • Prevalence
  • Retrospective Studies
  • Turkey / epidemiology